Abstract
Purpose: To understand how vitamin D influences the severity of dengue fever as per WHO 1997 and WHO 2009 classification, as many studies have shown ambiguity in this respect Method: The review has been registered in PROSPERO with registration number CRD420251003676 and will be carried out in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 standards. Peer-reviewed literature will be used to identify the studies. The literature search will be conducted using the following databases: Web of Science, PubMed, PubMed Central, and Scopus. Additionally, the academic search engine - Google Scholar will be searched; two reviewers will independently screen the titles and abstracts of studies based on predefined eligibility criteria. The other two reviewers will assess the quality based on the Joanna Briggs Institute quality parameters. Heterogeneity among the included studies will be examined using statistical measures such as I2 and Cochrane Q statistics. Sensitivity and subgroup analysis will be used to assess the findings’ reliability. If there are more than ten articles, a funnel plot test will be employed to assess publication bias. Conclusion: This systematic review and meta-analysis, in the absence of multi-centric studies, will explore whether Vitamin D deficiency worsens dengue outcomes and if supplementation could help. The findings from this study could help shape future treatments and improve patient care. In areas where dengue is endemic, our systematic review and meta-analysis will assist in pinpointing research gaps and direct future studies and public health initiatives.
Keywords: Dengue Fever, Dengue Haemorrhagic Fever, Vitamin D
Agarwal S J, Jena P K, Kishore J, Sahu L S, Behera C K, Panda S K, Agarwal V. Association between Vitamin D and Dengue Severity: A Systematic Review and Meta-Analysis Protocol. J Commun Dis. 2025;57(1):151-156.
DOI: https://doi.org/10.24321/0019.5138.202520
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